Cardiomyocyte Cell Cycle Activity and Nucleation in the Regenerating Giant Danio Heart
نویسندگان
چکیده
منابع مشابه
Cardiomyocyte Cell-Cycle Activity during Preadolescence
Earlier studies (Soonpaa et al., 1996) revealed a rapid drop-off of ventricular cardiomyocyte cell-cycle activity at birth in mice, followed by a burst of DNA synthesis during the first week of postnatal life which contributed to the formation of multi-nucleated cardiomyocytes by postnatal day 10 (PN10). It has recently been suggested that a second burst of cardiomyocyte cell-cycle activity occ...
متن کاملCardiomyocyte cell cycle
The adult mammalian heart has a limited capacity for replacing lost tissue following injury. Mammalian cardiomyocytes exit the cell cycle shortly after birth, where they undergo a final round of DNA synthesis, binucleate, and terminally differentiate. In addition, low levels of cardiomyocyte turnover in the aging heart or following injury seem to be mediated mostly by cardiomyocyte division. Al...
متن کاملCardiomyocyte cell cycle regulation.
Although rapid progress is being made in many areas of molecular cardiology, issues pertaining to the origins of heart-forming cells, the mechanisms responsible for cardiogenic induction, and the pathways that regulate cardiomyocyte proliferation during embryonic and adult life remain unanswered. In the present study, we review approaches and studies that have shed some light on cardiomyocyte c...
متن کاملTowards regenerating the mammalian heart: challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation.
In recent years, there has been a dramatic increase in research aimed at regenerating the mammalian heart by promoting endogenous cardiomyocyte proliferation. Despite many encouraging successes, it remains unclear if we are any closer to achieving levels of mammalian cardiomyocyte proliferation for regeneration as seen during zebrafish regeneration. Furthermore, current cardiac regenerative app...
متن کاملRegulation of mammalian cell cycle progression in the regenerating liver.
The process of cell division in mammalian cells is orchestrated by cell-cycle-dependent oscillations of cyclin protein levels. Cyclin levels are controlled by redundant transcriptional, post-translational and degradation feedback loops. How each of these separate loops contributes to the regulation of the key cell cycle events and to the connection between the G1-S transition and the subsequent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2012
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.26.1_supplement.lb64